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Dicentric Chromosome Assay by the Triage Methodology. A Potencial Tool in Large Scale Radiological Accidents

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  • laboratorios
  • dosimetría
  • proteccion radiologica
  • salud (publica)
  • carcinogenesis
  • cromosomas dicentricos
  • teratogenesis
  • mutagenesis







ARN (Argentina)


Cabitto, M


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The dicentrics and centric rings assay allows to estimate the absorbed dose in people

exposed to ionizing radiation from peripheral blood. In accidents with multiple victims, there

are methodologies that lead to increase the speed of response. One of them is the scoring of dicentrics chromosomes with triage criteria, which makes it possible to reduce analysis time. The aim of this approach is the classification of the victims in dose ranges of clinical

importance. The validation of this methodology was carried out through the participation of

the Biological Dosimetry Laboratory (BDL) of the Nuclear Regulatory Authority in three

intercomparison exercises: two of them organized by the Ministry of Health of Canada

(international) whose objective was the determination of the absorbed dose at 10 dose points with an X-ray source, in the range of 0 to 5 Gy; and one regional exercise organized by the BDL in which 2 dose points were evaluated with an Ir-192 source in a range of 0 to 0.5 Gy. XI Congreso Latinoamericano de Mutagénesis, Carcinogénesis y Teratogénesis Ambiental. Asunción, Paraguay, 25 al 27 de abril de 2019