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Inflammatory markers of radiation induced late effects

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  • efectos tardios de las radiaciones
  • piel
  • marcadores biologicos
  • inflamacion







ARN (Argentina)


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Up to now there is no established parameters for the follow-up of delayed radiation injuries . 1 Late toxicity is generally irreversible and can have devastating effects on

quality of life of people exposed either accidentally or during therapeutic radiation treatments . Histologically, late manifestations of radiation damage include fibrosis, necrosis, atrophy and vascular lesions. Although many etiologies have been

suggested regarding these late toxicities, persistent inflammation has been described as playing a key role. The recruitment of leukocytes from circulating blood is decisive in the inflammatory reaction.. All the steps in the recruitment cascade are orchestrated by cell-adhesion molecules (CAMs) on both leukocytes and endothelial cells, and different subsets of CAMs are responsible for different steps in extravasation. 2 A link between radiation –induced inflammatory processes and alterations in T-cell immunity are still demonstrable in the blood of A-bomb survivors. 3 The following study was conducted to examine the response of the immune system in the inflammatory reactions in patients with late skin injuries after radiotherapy or interventional fluoroscopy procedures The expression of adhesion molecules ICAM1 and 1-integrin on granulocytes and lymphocytes , as well as changes in subpopulations of T lymphocytes and the level of C-reactive protein , a well- studied inflammatory marker were evaluated. (14th International Congress of Radiation Research. Varsovia, Polonia, 28 de agosto al 1º de septiembre de 2011)