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Inflammatory Response Parameters in Cutaneous Radiation Syndrome

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  • proteccion contra las radiaciones
  • accidentes
  • inflamacion
  • arn argentina
  • sindrome de irradiacion







ARN (Argentina)


Dubner, D.; Molinari, A.; Rossini, A.; Michelin, S.; Portas, M


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Cutaneous Radiation Syndrome (CRS) is a possible complication post-radiation from accidental exposures, as has been demonstrated in numerous reported accidents and is also of concern in some settings of radiotherapy or interventional fluoroscopy procedures.

The cutaneous symptoms are based on a combination of inflammatory processes and alteration of cellular proliferation whose time course depends on several factors such as the radiation dose, individual radiation sensitivity, etc. Up to now there is no established parameters for the follow-up of the inflammatory response leading from acute to delayed radiation skin injuries. The involvement of cell-adhesion molecules (CAMs) in the recruitment of leukocytes from circulating blood is decisive in the inflammatory reaction and different subsets of CAMs are responsible for different steps in extravasation. The objective of this study was to identify parameters of the ongoing inflammatory process and

its usefulness as indicator of evolution and response of the patients to therapeutic treatment. It was conducted in 30 patients with acute and late skin injuries after radiotherapy (Rt) or interventional fluoroscopy procedures. The expression of adhesion molecules ICAM1 and β1- integrin on granulocytes and lymphocytes, as well as changes in subpopulations of T lymphocytes and the level of C-reactive protein were evaluated. International Experts’ Meeting on Radiation Protection after the Fukushima Daiichi Accident. Viena, Austria, 17 al 21 de febrero de 2014