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Effect of DTPA CaNa3 on the distribution of Ce-144 in the soluble cytoplasmatic fraction of isolated hepatocytes

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Etiquetas

  • activity levels
  • biological effects
  • cerium 144
  • clearance
  • decontamination
  • dtpa
  • gel permeation chromatography
  • liver
  • liver cells
  • radionuclide kinetics
  • rats
  • retention functions
  • scintillation counters
  • time dependence

Datos

Origen

Argentina

Idioma

Inglés

Organización

ARN (Argentina)

Autor

Dubner D.; Fernández Degiorgi C., Gómez Parada I. (Comisión Nacional de Energía Atómica, Buenos Aires (AR))

Previsualización

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Descripción

Numerous animal experiments and therapeutics applications have demonstrated the usefulness of DTPA CaNa3 to increase excretion of actinides and lathanides in cases of internal contamination. Because of the high affinity of these radionuclides for the liver, hepatocytes in primary culture was chosen as a simple model system. The purpose of this work was to study the distribution of Ce-144 between compounds of high and low molecular weight of the soluble cytoplasmatic fraction obtained from isolated hepatocytes after they were incubated with and without DTPA CaNa3, since the effectiveness of this chelating agent to remove contaminants is larger while they remain in this fraction.

Presentado en: 7. international congress of the International Radiation Protection Association; Sydney (Australia); 10-17 Apr 1988